It is a neuromuscular disease causing a gradual muscle weakness on the hindlimb and back, which is manifested by poor coordination of movements, cramped and asymmetric walking, or incontinence. The disease affects a wide range of dog breeds (described in more than 100 breeds) and start to develope at middle or upper age. Unfortunately, the disease is untreatable, it is gradually deteriorating, and after 3-5 years from the first manifestation of the disease, a death frequently occurs due to general weakness and paralysis of the respiratory muscles.
The test might be performed in a partner laboratory.
American Cocker Spaniel, Australian Shepherd, Boston Terrier, Coton de Tulear, Czechoslovakian Wolfdog, French Bulldog, German Shepherd, Irish Setter, Nova Scotia Duck Tolling Retriever, Poodle Miniature, Poodle Middle, Poodle Standard, Poodle Toy, Rhodesian Ridgeback, Saarloos Wolfdog, Siberian Husky, Staffordshire Bull Terriers, Thai Ridgeback, Welsh Corgi Cardigan, Welsh Corgi Pembroke, ...other breeds,
Gene and mutation
SOD1, exon 2