Rhodesian Ridgeback Panel
RIDGE, JME, DM, MH, DLOK, BLOK, HEMB, EOAD
RR-PANEL
Complete package of genetic tests for prevention of genetic health in Rhodesian Ridgebacks. The package includes genetic tests: Predisposition for Ridge (RIDGE) Juvenile Myoclonic Epilepsy (JME) Malignant Hyperthermia (MH) Degenerative Myelopathy (DM) D-Locus (DLOK) B-Locus (BLOK) Haemophilia B (HEMB) Early Onset Hearing Loss (EOAD)
Ridge predisposition
Ridge gene test, Ridgelessness, Dermoid Sinus predisposition
RIDGE
The ridge formation in Rhodesian and Thai Ridgeback is caused by mutation (duplication of stretch of DNA sequence including several genes). The mutation is called simply a ridge gene and shows dominant inheritance.
Juvenile Myoclonic Epilepsy
Myoclonic seizures
JME
The disease is characterized by myoclonic seizures, which cause rapid uncontrolled muscle jerks and twitches
Early Onset Adult Deafness
Hearing loss
EOAD
The genetic disease that is characterised by hearing loss early in life, in which affected individuals lose their sense of hearing within 1-2 years after birth...
Degenerative Myelopathy
DM
It is a neuromuscular disease causing a gradual muscle weakness on the hindlimb and back, which is manifested by poor coordination of movements, cramped and asymmetric walking, or incontinence.
B-locus
Liver nose, Brown
BLOK
The tested variant causes brown colouring of a nose ("livernose"), mucous membranes and claws. The inheritance is autosomal recessive (black allele and colour is dominant).
D Locus
Dilution, d1 allele
DLOK
The tested variant causes coat colour dilution. In black-coloured individuals of different breeds, the hair appears gray (blue)...
Malignant Hyperthermia
Canine stress syndrome
MH
It is a congenital disorder of skeletal muscle which is manifested by the significant increase in temperature (hyperthermia) up to 45°C, accelerated and irregular heart rate (tachycardia and arrhythmia), hyperventilation, muscle rigidity and may result in renal failure and death...
Haemophilia B
Christmas disease, Factor IX deficiency
HEMB
It is a rare blood disorder in which the blood is unable to clot properly, leading to excessive bleeding. Bleeding can be initiated from injury, trauma and surgery.
Inherited Ventricular Arrhythmia (RR IVA)
Arrhythmia, Sudden death
RR IVA
A research team led by Dr Kathryn Meurs described the genetic variant associated with Inherited Ventricular Arrhythmia in Rhodesian Ridgebacks (RR IVA)...
