It is a congenital disorder of skeletal muscle which is manifested by the significant increase in temperature (hyperthermia) up to 45°C, accelerated and irregular heart rate (tachycardia and arrhythmia), hyperventilation, muscle rigidity and may result in renal failure and death.
In genetically susceptible individuals, a particular group of volatile anesthetics may trigger the symptome. The inheritance of the disease is autosomal dominant.
American Cocker Spaniel, Australian Shepherd, Coton de Tulear, Czechoslovakian Wolfdog, French Bulldog, German Shepherd, Nova Scotia Duck Tolling Retriever, Rhodesian Ridgeback, Saarloos Wolfdog, Siberian Husky, Thai Ridgeback, Welsh Corgi, ...other breeds,
Gene and mutation